|Year : 2019 | Volume
| Issue : 2 | Page : 61-64
Postinfectious (Varicella Zoster) myositis and mixed polyneuropathy
Arti Muley, Palak Rajendra Doshi, Sunil Kumar, Sukhaswarup Kanojiya, Mrugal Vipul Doshi, Kinjal Patel
Department of Medicine, SBKS MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India
|Date of Submission||30-May-2019|
|Date of Decision||14-Aug-2019|
|Date of Acceptance||11-Sep-2019|
|Date of Web Publication||02-Jan-2020|
Dr. Palak Rajendra Doshi
Room No. 75, Vama Hostel, Sumandeep Vidyapeeth Campus, At and Po. Pipariya, Waghodia, Vadodara - 391 760, Gujarat
Source of Support: None, Conflict of Interest: None
We present a case of a 21-year-old male with weakness of all four limbs after primary episode of chicken pox. Nerve conduction studies and magnetic resonance imaging dorsal spine with whole spine and brain screening confirmed polyneuropathy and myositis, respectively. He responded well to intravenous steroids, with complete reversal of symptoms. This case shows that primary varicella zoster infection is a sufficient stimulus to drive antibody generation and precipitate clinical complications.
Keywords: Mixed polyneuropathy, myositis, varicella zoster
|How to cite this article:|
Muley A, Doshi PR, Kumar S, Kanojiya S, Doshi MV, Patel K. Postinfectious (Varicella Zoster) myositis and mixed polyneuropathy. J Integr Health Sci 2019;7:61-4
|How to cite this URL:|
Muley A, Doshi PR, Kumar S, Kanojiya S, Doshi MV, Patel K. Postinfectious (Varicella Zoster) myositis and mixed polyneuropathy. J Integr Health Sci [serial online] 2019 [cited 2020 Feb 29];7:61-4. Available from: http://www.jihs.in/text.asp?2019/7/2/61/274529
| Introduction|| |
Chicken pox is a viral infection which presents with fever and exanthematous rash which is extremely contagious. It is caused by a neurotropic human herpesvirus, the varicella zoster virus. The virus has the quality of remaining latent after the primary infection in the spinal and cranial ganglia and may be reactivated at a later stage in a state of immunocompromise to present as herpes zoster.
Neurological complications caused by chicken pox include cerebellar ataxia, encephalitis, transverse myelitis, aseptic meningitis, Guillain–Barre syndrome, meningoencephalitis, ventriculitis, optic neuritis, postherpetic neuralgia, herpes zoster ophthalmicus, delayed hemiparesis, peripheral motor neuropathy, myositis, cerebral angiitis, Reye's syndrome, and facial palsies.,, However, these are rare and are seen in only 0.01%–0.03% cases.
As per our knowledge, there has been no case which reported both polyneuropathy and myositis occurring simultaneously postvaricella. We present a case of 21-year-old male who developed both polyneuropathy and myositis at the same time after an episode of chicken pox.
| Case Report|| |
A 21-year-old unmarried male, mechanic by occupation, presented with a complaint of weakness and myalgia of all four limbs for 1 month. He was apparently well 1 month back when he suffered from fever with rash which was diagnosed as varicella zoster. Fever and rash recovered with treatment in a week. However, 7 days after the onset of rash, he developed pain, tenderness, and weakness in his left forearm followed by left hand muscles, so that the patient had difficulty in grasping objects with his left hand. 4–5 days later, he developed similar complaints in his right forearm and hand. 2–3 days after this, the patient developed pain and tenderness in both his thigh and calf muscles along with weakness of both lower limbs such that he had difficulty in walking and standing up from sitting position. At this time, he was investigated outside. His complete blood count (CBC), rheumatoid factor titer, serum uric acid, and serum calcium levels were normal. Urine examination revealed 6–8 pus cells/hpf and calcium oxalate crystals. He was given analgesics, but did not improve. 4–5 days after this, he presented to our hospital with the same complaints which had worsened in intensity. By this time, he had also developed difficulty in dorsiflexion of both feet. There was no bowel and bladder involvement and no history of headache, neck muscle rigidity, nasal regurgitation, altered speech, involuntary movements, diplopia, facial weakness, or asymmetry, but 4–5 days after admission, he developed mild dysphagia which was more for solids than liquids.
The patient gave a history of hepatitis B surface antigen-positive status detected in 2009. He had a family history of his sister having similar fever with rash 1 week after he had developed the same. She was also diagnosed and treated as varicella zoster and had recovered completely with no sequelae.
On examination, his pulse was 108/min and regular and adequate in volume in the right radial artery and blood pressure was 128/90 mmHg in the left arm in supine position. He had nonpitting edema over both forearm muscles and calf muscles with superficial warmth and tenderness [Figure 1].
|Figure 1: Swelling over the calf muscles and feet before starting corticosteroids|
Click here to view
Respiratory, cardiovascular, and per abdomen examination were unremarkable. On central nervous system examination, the higher mental function and cranial nerve examination revealed no abnormality. There was no muscle wasting, and tone in all four limbs was also normal. Power in all four limbs was 3+/5. Coordination could not be tested due to weakness. The knee and ankle jerks of both limbs were exaggerated, whereas the deep tendon reflexes of the upper limb, the jaw jerk, and the gag reflex were normal. There was loss of fine touch on dorsal (DL) aspect of both feet, whereas the rest of the sensory system examination was unremarkable. Babinski sign was negative in both the feet. A provisional diagnosis of postinfectious myositis or postinfectious neuropathy was kept in mind and the patient was investigated further on these lines.
His CBC showed slightly raised total leukocyte counts, but was otherwise normal. His urine examination, serum electrolytes, renal function tests, total protein/albumin, sickling, rheumatoid arthritis factor, and thyroid function tests were all normal. His liver function test showed normal bilirubin, but the serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase levels were raised slightly; C-reactive protein was also slightly raised, whereas serum calcium was reduced. Vitamin D3 levels were significantly low and Vitamin B12 levels were also on the lower side. Vitamin B12 and Vitamin D3 supplementations were given to the patient, but he did not show any significant improvement, rather his symptoms increased in intensity as the time passed. Hence, a cerebrospinal fluid (CSF) examination, nerve conduction study/electromyography (NCS/EMG), and magnetic resonance imaging (MRI) DL spine with whole spine and brain screening were done. The CSF examination was unremarkable, but the NCS/EMG was suggestive of mild demyelinating pure motor neuropathy and the MRI-DL spine with whole spine and brain screening showed the possibility of inflammatory myositis [Table 1]. The patient was given tablet acyclovir and intravenous corticosteroids for 5 days. With this, he showed a significant improvement in symptoms (probably due to myositis responding to steroids) with reduction of pain, tenderness, and swelling over the muscles with reduced difficulty in walking and dorsiflexion of the feet [Figure 2].
|Figure 2: Swelling over the calf muscles and feet decreased after 5 days of intravenous corticosteroid therapy|
Click here to view
After 5 days, he was discharged on oral corticosteroids and acyclovir with advice of physiotherapy. There was a gradual improvement after discharge, and on follow-up after 30 days, he was able to walk with support.
| Discussion|| |
Myositis is defined as an inflammation of voluntary muscles, which presents with pain, tenderness, swelling, and weakness of voluntary group of muscles. Infectious myositis may be due to wide variety of pathogens including bacteria, viruses, parasites, and fungi. Bacterial myositis presents as focal muscle infection, whereas viruses and parasites tend to cause diffuse disease with generalized myalgias and multifocal myositis. Viruses are reported as the most common etiologies of nonbacterial infectious myositis cases in the U.S. and the rest of the developed world. It may be caused by a variety of viral agents, including influenza (the most common etiology), parainfluenza, enteroviruses (coxsackievirus and echovirus), adenovirus, severe acute respiratory syndrome-coronavirus, HIV, herpes viruses (varicella, herpes simplex, Epstein–Barr, and cytomegalovirus), parvovirus B19, dengue, and West Nile virus., Although it results in spontaneous recovery in most of the cases, complications such as rhabdomyolysis, myoglobinuria, acute renal failure, cardiac arrhythmias, and compartment syndrome which could be potentially dangerous have also been associated with significant morbidity. Many explanations have been suggested as the pathogenic basis for these complications such as direct viral invasion or immune-mediated allergic mechanism. However, allergy-mediated injury has been reported to be the cause in most pathologic studies. However, most of the times, the neurological sequelae are in relation to reactivation of latent disease, whereas those following primary infection are rare.
This case presented with a combination of polyneuropathy and myositis, that too following the primary infection. It progressed to dysphagia also, but responded well to intravenous steroids. Hence, this case brings to notice that neurological complications postvaricella can occur even following primary infection and that one should keep high index of suspicion for detecting these as they are reversible with treatment without any residual involvement.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patientsunderstand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2]