Journal of Integrated Health Sciences

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 2  |  Page : 44--47

Analysis of creatinine clearance in patients on antimicrobial and analgesic therapy


S Priestly Vivekkumar1, Arvinth Arthanareeswaran1, E Sathya Suganya2, Anirudha Sathya Narayanan3 
1 Department of Pharmacology, Tagore Medical College and Hospital, Chennai, Tamil Nadu, India
2 Department of Community Medicine, Tagore Medical College and Hospital, Chennai, Tamil Nadu, India
3 IV Year M.B.,B.S, Tagore Medical College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Arvinth Arthanareeswaran
Department of Pharmacology, Tagore Medical College and Hospital, Chennai, Tamil Nadu
India

Background: Nephrotoxicity has become increasingly common due to indiscriminate use of drugs. Analgesic nephropathy is a unique drug-induced kidney disease which is characterized by renal papillary necrosis and interstitial nephritis resulting from prolonged excessive consumption of combination antipyretic analgesics. This study was done to assess the renal work load in hospitalized patients taking analgesics and antimicrobial medication by creatinine clearance and to find their consequences. Aim and Objectives: (1) To determine the proportion of participants having altered creatinine clearance. (2) To compare the creatinine clearance among the hospitalised patients on treatment with antimicrobials and analgesics. Materials and Methods: It was a cross sectional observational study in which 1200 patients were enrolled, divided into 2 groups, with Group A: Comprising of those under antibiotic treatment; with Group B: Comprising of those under analgesic treatment. Creatinine clearance was calculated by Modification of Diet in Renal Disease (MDRD) equation and CKD-EPI equation. Observation and Results: On analyzing the drugs causing renal impairment out of 1200 participants, it was found that among analgesics diclofenac (52%) and among antibiotics, aminoglycosides (61%), were more commonly resulting in renal dysfunction. Conclusion: According to the present study, it is clear that precaution has to be taken before initiating antimicrobials and analgesic therapy, as they are often nephrotoxic.


How to cite this article:
Vivekkumar S P, Arthanareeswaran A, Suganya E S, Narayanan AS. Analysis of creatinine clearance in patients on antimicrobial and analgesic therapy.J Integr Health Sci 2019;7:44-47


How to cite this URL:
Vivekkumar S P, Arthanareeswaran A, Suganya E S, Narayanan AS. Analysis of creatinine clearance in patients on antimicrobial and analgesic therapy. J Integr Health Sci [serial online] 2019 [cited 2020 Jun 2 ];7:44-47
Available from: http://www.jihs.in/article.asp?issn=2347-6486;year=2019;volume=7;issue=2;spage=44;epage=47;aulast=Vivekkumar;type=0