• Users Online: 104
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 8  |  Issue : 1  |  Page : 3-8

5-Fluorouracil-Induced hepatic perturbation: Protective potential of selenium


Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria

Correspondence Address:
Dr. Elias Adikwu
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JIHS.JIHS_30_19

Rights and Permissions

Background: Hepatotoxicity is a serious adverse effect that has characterized the therapeutic use of 5-fluorouracil (5-FU). Selenium (Se) has shown potential therapeutic benefits in animal models of some diseases. Aim: This study assessed the ability of Se to protect against hepatotoxicity induced by 5-FU in albino rats. Materials and Methods: Adult male albino rats (n = 40) were grouped and used. Group A (Control) was treated with normal saline (0.2 mL) intraperitoneally (i. p.) daily for 5 days. Group B (B1–B3) was treated with Se (0.125, 0.25, and 0.50 mg/kg i. p.) daily for 5 days, respectively. Group C was treated with 5-FU (20 mg/kg i. p.) daily for 5 days. Group D (D1–D3) was supplemented with Se (0.125, 0.25, and 0.50 mg/kg i. p) before treatment with 5-FU (20 mg/kg i. p.) daily for 5 days, respectively. After treatment, the rats were anesthetized; blood samples were collected for serum biochemical assessments. Liver was evaluated for biochemical parameters and histology. Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P < 0.001) increased in 5-FU-treated rats when compared to control. Liver glutathione peroxidase, superoxide dismutase, catalase, and glutathione levels were significantly (P < 0.001) decreased, whereas malondialdehyde levels were significantly (P < 0.001) increased in 5-FU-treated rats when compared to control. Hepatocyte necrosis occurred in 5-FU-treated rats. Nonetheless, 5-FU-induced alterations were significantly abrogated in a dose-dependent fashion in rats supplemented with Se 0.125 mg/kg (P < 0.05), 0.25 mg/kg (P < 0.01), and 0.50 mg/kg (P < 0.001) when compared to 5-FU-treated rats. Conclusion: Se may be effective against hepatotoxicity caused by 5-FU.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed580    
    Printed35    
    Emailed0    
    PDF Downloaded100    
    Comments [Add]    

Recommend this journal