Journal of Integrated Health Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 8  |  Issue : 1  |  Page : 3--8

5-Fluorouracil-Induced hepatic perturbation: Protective potential of selenium


Elias Adikwu, Nelson Clemente Ebinyo, Anerobi Fredrick Odira 
 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria

Correspondence Address:
Dr. Elias Adikwu
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State
Nigeria

Background: Hepatotoxicity is a serious adverse effect that has characterized the therapeutic use of 5-fluorouracil (5-FU). Selenium (Se) has shown potential therapeutic benefits in animal models of some diseases. Aim: This study assessed the ability of Se to protect against hepatotoxicity induced by 5-FU in albino rats. Materials and Methods: Adult male albino rats (n = 40) were grouped and used. Group A (Control) was treated with normal saline (0.2 mL) intraperitoneally (i. p.) daily for 5 days. Group B (B1–B3) was treated with Se (0.125, 0.25, and 0.50 mg/kg i. p.) daily for 5 days, respectively. Group C was treated with 5-FU (20 mg/kg i. p.) daily for 5 days. Group D (D1–D3) was supplemented with Se (0.125, 0.25, and 0.50 mg/kg i. p) before treatment with 5-FU (20 mg/kg i. p.) daily for 5 days, respectively. After treatment, the rats were anesthetized; blood samples were collected for serum biochemical assessments. Liver was evaluated for biochemical parameters and histology. Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P < 0.001) increased in 5-FU-treated rats when compared to control. Liver glutathione peroxidase, superoxide dismutase, catalase, and glutathione levels were significantly (P < 0.001) decreased, whereas malondialdehyde levels were significantly (P < 0.001) increased in 5-FU-treated rats when compared to control. Hepatocyte necrosis occurred in 5-FU-treated rats. Nonetheless, 5-FU-induced alterations were significantly abrogated in a dose-dependent fashion in rats supplemented with Se 0.125 mg/kg (P < 0.05), 0.25 mg/kg (P < 0.01), and 0.50 mg/kg (P < 0.001) when compared to 5-FU-treated rats. Conclusion: Se may be effective against hepatotoxicity caused by 5-FU.


How to cite this article:
Adikwu E, Ebinyo NC, Odira AF. 5-Fluorouracil-Induced hepatic perturbation: Protective potential of selenium.J Integr Health Sci 2020;8:3-8


How to cite this URL:
Adikwu E, Ebinyo NC, Odira AF. 5-Fluorouracil-Induced hepatic perturbation: Protective potential of selenium. J Integr Health Sci [serial online] 2020 [cited 2021 Jun 16 ];8:3-8
Available from: https://www.jihs.in/article.asp?issn=2347-6486;year=2020;volume=8;issue=1;spage=3;epage=8;aulast=Adikwu;type=0